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Determination of oxygen permeability in soft contact lenses using a polarographic method: Estimation of relevant physiological parameters

机译:用极谱法测定软性隐形眼镜的透氧性:相关生理参数的估计

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摘要

This work reports the apparent oxygen transmissibility Dk/t)app of four silicone hydrogel (Si-Hy) contact\udlenses (CLs). A method is described that allows the estimation of the oxygen tension at the lens-cornea\udinterface for closed- and open-eyelids situations combining the instrument oxygen transmissibility (IOT) and\udcorneal parameters such as corneal thickness, corneal permeability, and oxygen flux across the cornea. From\udthese results, the biological oxygen apparent transmissibility (BOAT), equivalent oxygen percentage (EOP),\udpartial pressure, (ptc), of oxygen at the cornea-CL interface and oxygen flux, (jc), were also obtained. This\udmethod allows the evaluation of the physiological environment under the lens using the formulations described\udin previous studies. The oxygen performance of four Si-Hy materials was evaluated using a polarographic\udcell coupled to a permeometer. Measurements of the apparent transmissibility, (Dk/t)app, and permeability,\udDk, were performed in stacks containing from 1 to n repeated lenses and, from the values obtained, the\uderror involved in the measurements in single samples was estimated. It was found that the values of\ud(Dk/t)app and Dk obtained following the two different procedures (stack method and measurement of\udsingle sample) were significantly different from the nominal values given by the manufacturer, particularly\udfor some samples. However, the impact of these differences on the values of the other physiologically relevant\udparameters (BOAT, EOP, ptc, and jc) was not significant. Furthermore, these parameters were similar\udfor the four lenses in spite of the different (Dk/t)app measured. The relationships of (Dk/t)app with the\udremaining physiological parameters were calculated and graphically represented for open and closed-eyelid\udconditions.
机译:这项工作报告了四个有机硅水凝胶(Si-Hy)接触\胶体(CLs)的视在氧气透过率Dk / t)app。描述了一种方法,该方法结合了仪器的氧气透过率(IOT)和\ udcorneal参数(例如角膜厚度,角膜通透性和氧气通量),可以估算出闭合和睁开眼睑情况下晶状体-角膜\ udinterface处的氧气张力穿过角膜。根据这些结果,还获得了角膜-CL界面处的氧气的生物氧表观透过率(BOAT),当量氧气百分数(EOP),等效压力(ptc)和氧气通量(jc)。该方法允许使用先前研究中描述的配方评估晶状体下的生理环境。使用与渗透计耦合的极谱/微电池评估了四种Si-Hy材料的氧性能。表观透射率(Dk / t)app和磁导率\ udDk的测量是在包含1到n个重复透镜的叠层中进行的,并根据获得的值估算单个样品的测量所涉及的uderror。结果发现,按照两种不同的程序(堆积方法和单样品的测量)获得的\ ud(Dk / t)app和Dk值与制造商给出的标称值有显着差异,特别是某些样品的\ ud 。但是,这些差异对其他生理上相关的\ u参数(BOAT,EOP,ptc和jc)的值的影响并不显着。此外,尽管测量的(Dk / t)应用不同,但四个镜片的这些参数相似。计算(Dk / t)app与剩余生理参数的关系,并以图形方式表示开眼和闭眼的\ ud条件。

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